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The free tripeptide was first identified in human plasma in 1973 by Loren Pickart as a factor supporting cell proliferation in liver cell cultures, and the copper-binding role of the peptide was recognized shortly afterward as the molecular basis for many of the activities attributed to GHK

It is found in nearly every cell in the human body, with the highest concentrations located in the liver

Yao et al, 1995

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In most cases, pregnancy-related pigmentation fades gradually after delivery