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Although the relationship of the identified proteins to GH and IGF-1 biological activity remains to be clarified further, the results suggest that they represent potential biomarkers of GH and/or IGF-1 action

Supplementary material The Supplementary material for this article can be found online at: Abbreviations AITD, Autoimmune thyroid disease

That difference compromises the integrity of peptide experiments because contaminated peptides can produce inflammatory artifacts, off-target effects, or simply degrade faster than expected

Still, many drugs that are poorly bioavailable in adults, are similarly so in infants

Whether that peptide is ever actually cleaved and released as an independent signaling molecule in living tissue is one of the fields genuinely unresolved questions, discussed in the limitations section below