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It plays a crucial role in mitigating the process of non-apoptotic cell death, colloquially termed ferroptosis, by counteracting the aggregation of lipid ROS and the subsequent occurrence of lipid peroxidation under oxidative stress conditions (181)

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Small intestinal microbiota: from taxonomic composition to metabolism

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208 PGC-1 has the ability to restrain the release of mtDNA from the mitochondria into the cytosol, oxidative stress, and increase TNFAIP3 (a negative regulator of NLRP3) to suppress NLRP3 inflammasome

Aging Biol