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The Lichtiger Colitis Activity Index was used to assess variables at baseline, week 4, and week 8

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Preclinical studies have explored downstream effects on antioxidant signalling, extracellular matrix remodelling, and gene-expression responses in cultured cells

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Baseline liver function tests (AST, ALT, bilirubin), glutathione peroxidase activity, malondialdehyde (oxidative stress marker), and cysteine levels provide clinical context

These sensations occur when blood vessels near the skin surface dilate suddenly, bringing more blood to the surface and releasing heat