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IAA causes neurotoxicity through a variety of mechanisms, including oxidative stress, DNA damage, inflammation, BBB disruption, and apoptosis
Meanwhile, the FDA's own career scientists are recommending against giving compounding pharmacies the green light to produce any of the seven peptides under consideration
Comparison with atorvastatin binding to HMG-CoA reductase, its intended target, offers clues on how to modify the statin to reduce RyR1 binding, while leaving binding to HMG-CoA reductase unperturbed
Secondly, the combination of different functional nanoagents may cause corresponding toxic side effects to the human body, thus the biodegradability, stability, and safety of nanomedicines still need further validation
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