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Thus, we exposed human neural progenitor cells (hNPCs) to increasing doses of VPA from 50 M to 5 mM, representing concentrations of VPA below, within, and above the therapeutic range used to treat epilepsy [70]

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Clinically, patients possessing microbiota with enriched biosynthetic capacity for these metabolites exhibit superior glycemic responses, positioning microbiome profiling as a promising predictive biomarker for treatment stratification

We propose that the activity of these cysteine proteases is dependent on the pH and protease activity of a fully functional digestive vacuole, and that normal DV formation is impaired in K13-mutant parasites 7