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If liver fat reduction is a key objective, retatrutide offers substantially greater hepatic fat clearance than tirzepatide, as discussed above

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This capacity of FcRn antagonists to modulate the pharmacokinetics of other IgG-based Ab therapeutics was investigated in a phase I clinical trial (NCT04973566) addressing the effect of nipocalimab on the pharmacokinetics of the IgG Fc-fusion etanercept, which consists of the extracellular domains of tumor necrosis factor-alpha receptor 2 fused to an IgG1 Fc

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then, the mixture was centrifuged at 1500 g for 10 min at 4C to collect the supernatant