Contraindications include active cancer, pregnancy, and certain autoimmune conditions
The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss
XY: Conceptualization, Supervision, Writingoriginal draft
It is not a stabilized peptide but a small molecule ERR receptor agonist, designed from the start for the oral route
Fabbrini E, Serafini M, Colic Baric I, Hazen SL, Klein S
Besides ATF4, another transcription factor that regulates xCT expression is the nuclear factor erythroid 2-related factor 2 (NRF2) via the antioxidant response element (ARE) present in the promoter region of xCT gene (40, 41)