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When liver function is sluggish or overwhelmed, hormones can accumulate and drive pigmentation

A., & Sullivan, D

Effect of 6'-acetylpaeoniflorin on dinitrochlorobenzene-induced allergic contact dermatitis in BALB/c mice

New England Journal of Medicine 377: 12171227

These strategies are based on leveraging existing molecular pathways, thereby avoiding some of the pitfalls of supplementing the lens with exogenous antioxidants, which have shown mixed results