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e , Schematic showing how the iron-sulfur cluster-containing protein LIAS enables OGDH and PDH activity by transferring lipoic acid as a cofactor to their enzyme complexes (left)

Conversely, TP53 can suppress ferroptosis by inhibiting dipeptidyl peptidase 4 (DPP4) activity or inducing cyclin dependent kinase inhibitor 1A ( CDKN1A , also known as p21) 157,158

Many of these relate to tissue remodeling, antioxidant response, and anti-inflammatory pathways

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Liver biopsy is the diagnostic gold standard for fibrosis

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