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Rescue medication was available for patients whose fasting plasma glucose exceeded the predefined limits of 15.0 mmol/L from week 8, 13.3 mmol/L from week 9 to week 20, and 11.1 mmol/L from week 21 to week 32

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7 Conclusion This manuscript addresses the mechanisms of renal aging including oxidative stress, reduced Klotho levels, cellular senescence, as well as chronic inflammation

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