At 10 percent concentration with the same application schedule, consumption rises to approximately 1.4 grams per month
Preservation of Insulin and Glucose Homeostasis Unlike growth hormone, which can cause insulin resistance and elevated blood glucose (diabetogenic effects), AOD-9604 has demonstrated no negative effects on carbohydrate metabolism
This can also affect vitamin B12 absorption
GLP-1 receptor agonists such as Saxenda and Wegovy work, with clinical trial evidence behind them roughly 6% and 16% body weight reduction respectively over 68-week trials
This is a commonly referenced study from 1963 claiming a half-life of 5-6 days: nature.com/articles/198200a0 Although I would not cite it as an authority, the six-day half-life has also made it onto the B12 page in Wikipedia, seemingly unchallenged
Rates of deficiency increase with age