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Since adiponectin increases cellular sensitivity to insulin [37, 125,126,127] and also possesses anti-atherogenic effects [128,129,130], a marked reduction in the circulatory concentrations of adiponectin results in IR and atherosclerosis via systemic inflammation [115]

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This process is vital for preventing the accumulation of toxic substances that can lead to liver disease and other health issues

Supplemental doses usually range from 0.5 to 2 g/day (133)