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Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes

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In lupus nephritis(LN), the researchers treated NZB/W lupus mice with a selective histone deacetylase 6 (HDAC6) inhibitor for 4 weeks and showed that HDAC6 inhibition decreased B-cell activating signaling pathways, resulting in a significant reduction in LN symptoms (52)