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Angew Chem Int Ed 55(27):76067630

In chronic wounds, a 2021 RCT (n=72 diabetic ulcers) reported 85% closure rate with GHK-Cu dressings at 12 weeks versus 55% control (OR 4.2

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In addition, 1,25(OH)2D3 induces the release of neurotrophin and synthesis of Ca 2+ -binding proteins such as parvalbumin, inhibits the synthesis of inducible iNOS, macrophage colony-stimulating factor, TNF-, down-regulates L-type voltage sensitive Ca 2+ channel (LVSCC), and upregulates -glutamyl transpeptidase activity, which are also reported to be the potential neuroprotective mechanisms of VD in PD (Figure 2A) (9193)

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10.1016/S0960-0760(03)00229-2 243