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doi: 10.3390/antiox9070624

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One of the characteristics of DAM is the expression of TREM2, which marks a distinct population of microglia and macrophages

10.3390/molecules27062032 89 NovianaE.IndrayantoG.RohmanA

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Mechanistic investigations using Sprague-Dawley (SD) rats have revealed that this hypocholesterolemic effect is primarily mediated through the inhibition of hepatic cholesterol biosynthesis pathways ( in vitro experimental data have further demonstrated that water-soluble OSCs, particularly SAC, effectively suppress cholesterol synthesis ( in vitro and in vivo findings suggests that SAC may represent the primary bioactive component responsible for AGE-mediated plasma cholesterol reduction ( Furthermore, allicin has been shown to ameliorate lipid metabolic disorders in HepG2 cells induced by 1,3-dichloropropanol exposure, as evidenced by significant reductions in both TG and TC levels ( Current research indicates that OSCs like allicin and DADS modulate the lipid metabolic process of HepG2 cells via pathways such as AMPK-SREBPs and MEK1-ERK1/2-ELK-1, resulting in effective lipid-lowering effects