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Liver biopsies in most dogs revealed centrilobular degeneration and necrosis, with intrahepatic cholestasis but no inflammation

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177,178,179 Meanwhile, the transcript levels of genes involved in mitochondrial protein import, such as Tomm40l, Timm44, and Timm8a1, and the transcript levels of Mfn2, Opa1, Drp1, and Fis1 are decreased in PGC-1 selectively ablated skeletal myofibers

Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells