(2016) The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells, Free Radic
pylori has a number of virulence genes which express effector proteins that directly destroy the gastric epithelium (Whitmire and Merrell 2019)
One animal study (Valdecantos et al., ADA 2024) showed obese rats given both compounds at sub-maximal doses lost more weight than either compound alone
Elancheran, Kasturi Dutta, Prashanta Kumar Deb, Rajlakshmi DeviFrontiers in Pharmacology vol: 13 year: 2022 doi: 10.3389/fphar.2022.1009023 3
204 Challenges and future directions toward clinical translation Although the gut microbiome shows immense potential as biomarkers for liver disease, its move toward large-scale clinical application still faces multiple challenges such as standardization, causality, and personalization
Statistical analysis All analyses were conducted using the RStudio version 1.4.17.17 software by the packages meta and metafor. We used the method suggested by the Cochrane handbook to calculate the sample size and event [19]
,aspect=ignore)
