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Chromatin immunoprecipitation demonstrated a marked enrichment of H4K5la at the COL1A1 promoter, driving its transcription and promoting extracellular-matrix remodeling, actin reorganization, and aggressive tumor proliferation and invasion

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Consequently, evidence supporting essentiality is assembled on the AOP page, rather than on the independent KE pages that are meant to stand-alone as modular units without reference to other KEs in the sequence