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The sample size was based on a compromise between feasibility, precision, and regulatory considerations 52 , and an estimated 12-month recruitment timeline

Unfortunately, chemotherapy alone is often unsatisfactory, with intrinsic and acquired resistance to conventional chemotherapeutic agents and targeted drugs developing in a short period of time

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The suppression of antioxidant proteins, glutathione synthesis enzymes, and NADPH-producing enzymes would lead to ROS accumulation in cancer cells and subsequent oxidative damage to various intracellular components, thus compromising the cell viability

doi: 10.1016/s1350-9462(02)00042-3

Clin Kidney J