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It is possible that bypassing the inhibitory actions of IGF-binding proteins with IGF-I LR3 may allow for better-supported activation of IGF signaling pathways that contribute to a reduction in contraction-induced damage

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Correspondingly, antioxidant defenses such as GSH, CAT, and SOD were markedly reduced in these groups, with GSH decreasing to 1.557 0.26 in BPA 100 and further to 0.685 0.04 in BPA 300, and CAT and SOD showing significant declines as well