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Zukun Chen, [email protected]

Exceeding this dose can lead to serious problems due to a metabolite of the drug being toxic to the liver

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We show that adaptation to acetaminophen has a spatial component, involving a shift in regionalisation of CYP2E1, which may prevent toxicity thresholds being reached

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These studies underscore that the effects of serine might depend on the type of infiltrating immune cells (Tregs or Teffs) and their specific isomer, being an interesting target for supplementation in tumors with a high ratio of infiltrated Teffs/Tregs