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534 Mechanistically, metformin enhances autophagy, promoting clearance of immune complexes and dysfunctional organelles, thereby reducing inflammatory burden

Glutathione protects against infections by enhancing immune cells' ability to recognise and eliminate pathogens such as bacteria, viruses, and fungi

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As a result, the study provided useful information for enhancing the safety and efficacy of isotretinoin treatment, as well as lowering isotretinoin-related side effects