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If your symptoms are due only to vitamin B12 deficiency, there is a high chance of improvement

Both choline and methionine are a source of methyl groups for the one-carbon transmethylation pathway and serve hepato-protective functions

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

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Canadian athletes training outdoors during winter months already receive significant cold exposure