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Graying occurs when the melanocytes (cells responsible for hair color) stop producing melanin or when hydrogen peroxide builds up in the hair follicle, essentially "bleaching" the hair from the inside out

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Current research has found aerobic exercise intervenes in MAFLD through multiple signaling pathways (Table 1)

They also found that HMGB1 knockdown inhibited the high glucose-induced toll-like receptor 4 (TLR4)/NF-B signaling pathway and promoted the expression of Nrf2 and its downstream targets, such as HO-1, NQO1, glutamate-cysteine ligase catalytic subunit (GCLC) and modifier subunit of glutamate cysteine ligase (GCLM)[86]

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