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Myeloid-derived suppressor cells (MDSCs) and activated tumor-associated macrophages express ARG1, which consumes arginine to form a microenvironment that is not conducive to T cells, resulting in tumor immunosuppression (Rodriguez et al., 2017

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doi: 10.1179/1351000212Y.0000000029

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Importantly, these compounds stimulate endogenous GH release, which mimics the bodys natural pulsatile secretion of growth hormone

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