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It will be interesting to determine whether aging increases DNA methylation of astrocyte-secreted Wnt factors, which might explain the lower rate of neurogenesis in old brain (Zhao et al., 2008) and the observation that early postnatal astrocytes are more efficient in promoting the in vitro neuronal differentiation of NPCs than astrocytes derived from the adult brain (Song et al., 2002)

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Their use should involve appropriate professional guidance, even though some products containing these peptides are available over the counter