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In hepatocellular carcinoma, tumor-derived lactate induces H3K18la in TAMs, which transcriptionally activates NUPR1 and upregulates immunosuppressive mediators (e.g., IL10, TGF-, Arg1), thereby impairing CD8 T-cell activation [164]

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Badole SL, Chaudhari SM, Bagul PP, Mahamuni SP, Khose RD, Joshi AC, et al

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Wang et al., 2021b) and first reported that Pd-based nanozyme can imitate GSH peroxidase with robust catalytic activity