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In the past decades, most studies on the mode of cell injury have been limited to necrosis and apoptosis

Higashi Y, Aratake T, Shimizu T, Shimizu S, Saito M

2 The discovery of ferroptosis The concept of ferroptosis was formally proposed by Dixon in 2012 ( 3 Ferroptosis regulation mechanism Ferroptosis is a controlled iron-dependent lipid peroxidation cell death controlled by many metabolic pathways, such as redox reactions, iron homeostasis, glutathione metabolism and lipids ( Figure 1 )