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doi:10.1016/j.bcp.2018.05.003 Neelakantan H, Brightwell CR, Graber TG, et al

It is a comparatively recent discovery and a fast-growing subject of metabolic and longevity research

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Tolerability (early human safety): Short human studies reported a placebo-like safety profile with no serious adverse events [5] [6]

Treatment recommendations are based on provider evaluation, medical history, current medications, and clinical judgment

Other risk factors include age, digestive issues like Crohns disease, or medications that interfere with B12 absorption