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Gamma-butyrobetaine dioxygenase is promiscuous in substrate selectivity and it processes a number of modified substrates, including the natural catalytic products L-carnitine and D-carnitine, forming 3-dehydrocarnitine and trimethylaminoacetone

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It is an anatomically small brain region that contains widespread projections to multiple brain regions, thus activating this single site has the potential to result in widespread brain activation [93]

Due to their strong dd transitions, MnO nanostructures are commonly applied as quenchers in turn-off/on fluorescence probes [69]

Most patients describe the treatment as tolerable