In 2020 another open-label RCT of triple therapy with or without NAC, 1200 mg per day, was published, and reported that addition of NAC did not improve eradication rates
Similarly, genealogic analyses and twin studies have shown a genetic link between ME/CFS patients and their offspring, ensuing a heightened risk of developing ME/CFS in the offspring (26, 66, 69)
V.KrebsH
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Potential mechanisms for this interaction include (1) cooperation between germline and somatic variants in different pathways to promote a clonal advantage 318 , (2) germline variants acting downstream of somatic variants to modulate clonal advantage (and vice versa), (3) germline variants promoting the formation of larger-scale somatic events such as chromosomal abnormalities 177 , and (4) germline variants (for example, in DNA repair pathways) contributing to clonal advantage, agnostic to the nature of the somatic mutation driving the clone
Schultz T