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Kashyap P, Kumar S, Riar CS, Jindal N, Baniwal P, Guin RP, Correia PM, Mehra R, Kumar H

Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178

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The nitric oxide generated through this pathway proves essential for BPC-157's pro-migratory effects on endothelial cells, creating a permissive vascular environment for tissue regeneration