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Pollard, J.D., Quan, S., Kang, T., & Koch, R.J

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Pharmacological inhibition of cyclophilin D using cyclosporine A provided only temporary protection in vitro66, but cyclophilin D-deficient mice were protected against liver injury when treated with a moderate APAP overdose of 200 mg/kg68

Further follow-up data are required to establish the severity of tissue fragility complications compared with patients with other recognized molecular causes of vEDS

Ongoing laboratory investigations continue to explore its relevance in controlled biochemical research environments and peptide-signalling pathway analysis

doi: 10.1016/0005-2760(82)90150-3 22 LiYFanWGuXLiuSHeTGouSet al