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This finding is consistent with studies showing that histone acetylation is contingent upon the glucose metabolism-related enzyme ATP-citrate lyase [110] (Fig

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KPV represents a tripeptide fragment derived from the C-terminal region of alpha-melanocyte stimulating hormone (-MSH), consisting of the amino acid sequence lysine-proline-valine with molecular formula C16H30N4O4 and molecular weight of 342.43 g/mol

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Moreover, genes associated with NADH consumption or conversion to NADPH, including LDHA, BADH (ALDH9A1), NNT and NADK2, were also upregulated by metformin treatment in intestinal tissues (Supplementary Fig

Machado, R