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Absorption across the gut epithelium, first-pass liver metabolism, and systemic distribution are all separate steps that determine whether an orally administered compound reaches target tissues at meaningful concentrations

The exceptions come down to what irritates the injection site

After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated

Short answer: cycling is the reasonable approach, but not for the dramatic reasons people usually give

People with a deficiency often experience fatigue and weakness