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We then characterized the antiviral activity of clofazimine in two cell lines that are more physiologically relevant to coronavirus diseases: cardiomyocytes derived from human embryonic stem cells and human primary small-airway epithelial cells, which robustly support SARS-CoV-2 20 and MERS-CoV 21 replication, respectively

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Indeed, CARS2 inhibition in KEAP1-NRF2-intact cells decreased the mitochondrial membrane potential and oxygen consumption rate (Akaike et al

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SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

On the other hand, adhesion to the extracellular matrix allows cells to survive and proliferate