Oxidative stress biomarkers including superoxide dismutase, glutathione reductase, total antioxidant capacity, and catalase activities were also significantly impaired
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However, due to therapeutic stress-induced acquired genomic alterations, targeting EGFR monoclonal antibodies and TKIs (tyrosine kinase inhibitors) often leads to the emergence of clinical resistance [89]
The addition of GIP agonism is what separated tirzepatide from pure GLP-1 drugs, and researchers tracking the progression from semaglutide to tirzepatide to retatrutide can see how each additional receptor adds another layer of metabolic benefit
Several classes of antidepressant drugs have been implicated in the serotonin syndrome, including serotonin reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors) [183,184]
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