R., Gan, R
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Research to date highlights MOTS-cs ability to promote metabolic homeostasis (improving insulin sensitivity, encouraging fat utilization, and preventing diet-induced metabolic disorders) as well as its potential to mitigate aspects of aging (preserving muscle function, bone density, vascular health, and more)
Once fibrin is formed, it binds to the platelet clot and forms a very stable matrix that enhances wound healing
However, enhanced local retention may also promote chronic accumulation and consequently raise potential safety concerns
As a potent damage-associated molecular pattern, the released mtDNA can further amplify the inflammatory signal and serve as a structural component of neutrophil extracellular traps (NETs), thus creating a self-amplifying loop of netosis (116, 117)