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If clinical improvement is absent, if there is a history of prolonged supplementation, or if semen parameters deteriorate despite treatment, it may be necessary to reassess antioxidant therapy and consider investigating RS [72]

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Bartalena, L., Marino, M., Marcocci, C

Indeed, deletions or mutations of the SHANK3 gene have been found both in patients with PMS, which occur in over 50% of ASD patients [338], and in ASD patients outside the PMS

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