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The parallel decline in endogenous GHK-Cu levels is suggestive, though causation has not been established

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What the Drug Interaction Databases Say Major drug interaction databases (Lexicomp, Micromedex, Clinical Pharmacology) do not list a GHK-Cu/metformin interaction

For example, melatonin supplementation has been found to increase the expression of genes such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), and pentraxin 3 (PTX3) (77)

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