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However, when the limit for storage of TAGs is reached or adipocyte lipolysis is dysregulated, FAs can accumulate in ectopic tissues such as skeletal muscle and the liver leading to insulin insensitivity and T2D (11)

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The Pan African Medical Journal

Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis