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Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)
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The direct infusion of glutathione via IV can enhance its bioavailability, delivering the compound more effectively to where its most needed in the body
In a cell line study, NAC has shown the potential to reduce the dysfunction of both dopamine and glutamate by enhancing dopamine receptor binding and neuronal viability (181)
Generation and quantification of GSH, GSSH, persulfide and polysulfides from reaction of GSH and Na 2 S GSH (10 M) in 400 L of 50 mM HEPES buffer (pH 7.4) was reacted with Na 2 S 2 (1030 M) for 5 min at RT in a 2 mL capacity 96-well plate under argon sealed with parafilm
