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How This Works FOXO4-DRI is a synthetic peptide that selectively targets senescent cells by blocking the FOXO4p53 protein interaction [1] [2]

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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

Longevity peptides (Tier 1) are often cycled rather than used continuously

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Animal studies have shown that the peptide exhibits anti-tumor activity and inhibits the expression of carcinogenic receptors [13]