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Ng, Journal (Endocrinology, Volume 142, Issue 12, December 2001, Pages 51825189)

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it is a documented range, and the research literature has not established an optimal daily frequency for any human goal

Some individuals report a sensation of body swelling or warmth, but these symptoms typically resolve on their own within a few hours

Clinicians therefore need to know not only the half-life of the drug that they are prescribing but also what the half-life might be given the presence of one or more of these factors in the patient to whom the drug is being prescribed