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Given that glutathione is a tripeptide composed of glutamate, glycine, and cysteine, glutamine-derived glutamate and cysteine need to be ligated by glutamate-cysteine ligase (GCL), which itself comprises two separately encoded proteins: a catalytic subunit (GCLC) and a modifier subunit (GCLM) 53,54

The sequence of the UTR reveals use of multiple promoters that are regulated in a tissue-specific manner

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The Trx system also reduces peroxiredoxins which control reactive oxygen species (ROS) and hydrogen peroxide levels 19

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