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By inhibiting NNMT, 5-Amino-1MQ is theorized to spare nicotinamide for NAD+ synthesis , raising intracellular NAD+ and activating SIRT1 (Sirtuin 1) pathways tied to mitochondrial biogenesis and fat oxidation [3]

Am J Pathol 163(5):18011815 St Croix B et al (2000) Genes expressed in human tumor endothelium

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