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These cells accumulate with age and contribute to various age-related diseases, including those affecting the joints

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Interestingly, p53 3KR , an acetylation-defective mutant form of p53 (K117R, K161R, and K162R), effectively suppressed the expression of SLC7A11 but not other target genes of p53 [119]

Iijima H, Duguet A, Eum SY, Hamid Q, Eidelman DH: Nitric oxide and protein nitration are eosinophil dependent in allergen-challenged mice