5-amino-1mq nnmt inhibitor research | Purity ≥98% 5-AMINO-1MQ (5A1MQ, 5-amino-1-methylquinolinium iodide, NNMT

References ACS Chemical Biology (2023) Synthetic ERR// Agonist Induces an ERR-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Journal of Pharmacology and Experimental Therapeutics (2024) A Synthetic ERR Agonist Alleviates Metabolic Syndrome Circulation (2024) Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function American Journal of Pathology (2023) Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

[8] Early small-scale research suggested it may stimulate lipolysis (the breakdown of fat) and inhibit lipogenesis (fat storage), with preliminary data indicating it may not significantly affect blood glucose or insulin-like growth factor-1 (IGF-1) levels

In obesity, NNMT activity is unusually high in fat cells, which means a lot of nicotinamide gets thrown out before it can be turned into NAD+

For physiological reasons, dietary vitamin B12 generally cannot cause hypercobalaminemia

A healthcare professional can prescribe vitamin B12 intramuscular injections or nasal gel spray for people with a severe vitamin B12 deficiency

Neither point is a claim that it works in humans