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Typical shot schedules use a short loading phase (26 weeks) followed by monthly to every 23 months maintenance (AAFP

Patients will often say it hasnt worked on subsequent review, but this can mean anything from it didnt help even for ten minutes to it was great for two weeks but then the pain recurred and is now no better

Guideline 5: Treatment Duration Planning Planning the treatment length is vital

9 Getting a B12 Shot Earlier in the Day Will Decrease the Chance of Insomnia B12 shots do not contain any stimulants , but depending on how sensitive you are, getting the shot in the evening may lead to vivid dreams or insomnia

As noted, the present knowledge is limited, and these are considerations, not strong recommendations